Our publications

Recent Research Papers

• Yheskel, M., Hatch, H.A.M., Pedrosa, E., Terry, B.K., Siebels, A.A., Zheng, X.Y., Block, L.E.R., Fencková, M., Sidoli, S., Schenck, A., Zheng, D., Lachman, H.M., and J. Secombe (2024). KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons. Nucleic Acids Research, Apr 10, 1-19. PMID:38597673 

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• Rogers, M.F., Marshall, O.J., and J. Secombe (2023). KDM5-mediated activation of genes required for mitochondrial biology is necessary for viability in Drosophila. Development, doi.org/10/1242/dev.202024

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• Yheskel, M,. Sidoli, S., and J. Secombe (2023) Proximity labeling reveals a new in vivo network of interactions for the histone demethylase KDM5. Epigenetics & Chromatin, 10.1186/s13072-023-00481-y.

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• Schneider, B.K., Sun, S., Lee, M., Li, W., Skvir, N., Neretti, N., Vijg, J., and J. Secombe (2023) Expression of transposons contributes to aging in Drosophila. Genetics. 10.1093/genetics/iyad073

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• ​Hatch, H.A.M., O’Neill, M.H., Marion, R.W., Secombe, J.#., and L.H. Shulman# (2021) Caregiver-reported characteristics of children diagnosed with pathogenic variants in KDM5C. American Journal of Medical Genetics - Part A, doi:10.1002/amjg.a.62381 PMID:34089235   # co-corresponding authors.

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• Hatch, H.A.M., Belalcazar H.M., Marshall O.J., and J. Secombe (2021) A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation. eLife doi.org/10.7554/elife.63886 PMID: 33729157 

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• Belalcazar, H.M., Hendricks, E.L., Zamurrad, S., Liebl, F.L.W., and J. Secombe (2021) The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction. Cell Reports, 34(7):108753. DOI:10.1016/j.celrep.2021.108753. PMID:33596422

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• Drelon, C., Rogers, M.F., Belalcazar H.M., and J. Secombe (2019) The histone demethylase KDM5 controls developmental timing by promoting prothoracic gland endocycles. Development, 146:dev182568 doi: 10.1242/dev.182568. PMID:31862793

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• Chen, K., Luan, X., Liu, Q., Wang, J., Chang X., Snijders A. M., Mao J-H., Secombe J., Dan Z, Chen J-H., Wang Z., Dong X., Qiu C., Chang X., Zhang D., Celniker S. E., and Xingyin Liu (2019) Drosophila KDM5 regulates social behavior through immune control and gut microbiota maintenance. Cell Host & Microbe 25, 1-16. PMID:30902578

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• Drelon, C., Belalcazar, H.M. and J. Secombe (2018) The histone demethylase KDM5 is essential for larval growth in Drosophila. Genetics, 209, 773-787. PMID:29764901 

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• Zamurrad, S., Hatch, H.A.M., Drelon, C., Belalcazar, H.M, and J. Secombe (2018) A Drosophila model of intellectual disability caused by mutations in the histone demethylase KDM5. Cell Reports 22, 2359-2369.  PMID:29490272.

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• Navarro-Costa, P., McCarthy, A., Prudêncio, P., Greer, C., Guilgur, L.G., Becker J., Secombe, J., Rangan, P and R. Martinho (2016). Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodeling. Nat. Comms., 10;7:12331. PMID:27507044.

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• Liu, X., and J. Secombe (2015). The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif. Cell Reports, 13, 2219-2231. PMID: 26673323. 

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• Liu, X., Greer, C., and J. Secombe (2014). KDM5 interacts with Foxo to modulate cellular levels of oxidative stress. PloS Genetics, 10(10):e1004676. PMID:25329053

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• Li, L., Anderson, S., Secombe, J and R.N. Eisenman (2013) The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Development 140:1-12.  PMID:24173801

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• Greer, C., M. Lee, M. Westerhof, B. Milholland, R. Spokony, J. Vijg and J. Secombe (2013) Myc-dependent genome instability and lifespan in Drosophila.  PloS ONE 8(9): e74641. PMID:24040302.

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• DiTacchio, L., Le, HD., Vollmers, C., Hatori, M., Witcher, M., Secombe, J. and Panda, P. (2011) Histone lysine demethylase JARID1a activates transcription regulators CLOCK-BMAL1 and influences the circadian clock. Science, 333:1881-1884. PMID:21960634

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• Li, L., C. Greer, R.N. Eisenman and J. Secombe (2010) Essential functions of the histone demethylase Lid. PloS Genetics 6(11):e1001221. PMID:21124823.

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• Secombe, J., L. Li, L. Carlos and R.N. Eisenman (2007) The Trithorax protein Lid is a trimethyl H3-K4 demethylase required for dMyc-induced growth. Genes Dev. 21:537-551. PMID:17311883.

 

Reviews

• Hatch, H. A. M., and J. Secombe (2021) Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes-Jensen syndrome. FEBS J. doi:10.111/febs.16204 PMID: 34536985

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